| W | = | Weekend Gross |
| T | = | Total Gross |
|
| 1 | Iron Man
W:$50.5M T: $177M |
| 2 | Speed Racer
W:$20.2 T:20.2M |
| 3 | What Happens in Vegas...
W:$20 T:20M |
| 4 | Made of Honor
W:$7.6T:26.3M |
| 5 | Baby Mama
W:$5.77T:40.4M |
| 6 | Forgetting Sarah Marshall
W:$3.78T:50.7M |
| 7 | Harold & Kumar Escape from Guantanamo Bay
W:$3.15 T:30.7M |
| 8 | The Forbidden Kingdom
W:$1.9 T:48.3M |
| 9 | Nim's Island
W:$1.32 T:44.3M |
| 10 | Redbelt
W:$1.14 T:1.24M |
